This issue was troubleshooted on the ynput community discord. I’ll just add the solution here, for anyone that might run into a similar issue in the future.
When accessing Ayon through the Synology DSM reverse proxy, AYON would time out at times, which resulted in getting an indefinite loading screen and you’d be forced to reload the page.
The issue was the ayon frontend connecting to the backend using websockets and that connection timed out.
The solution was adding two entries under the Custom Header in the reverse proxy options in Synology DSM.
Upgrade = $http_upgrade
Connection = $connection_upgrade